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18-Deoxyaldosterone

Clinical data
Other names	11β,18-epoxy-21-hydroxypregn-4-ene-3,20-dione, 11β-11,18-epoxy-21-hydroxypregn-4-ene-3,20-dione, 11β,18-epoxy-21-hydroxy-progesterone, 21-hydroxy-11β,18-oxido-4-pregnene-3,20-dione
Drug class	Antimineralocorticoid
Identifiers
CAS Number	2507-88-2
PubChem CID	188963
ChemSpider	164193
UNII	S4YT68R2XR
CompTox Dashboard (EPA)	DTXSID30947934
Chemical and physical data
Formula	C21H28O4
Molar mass	344.451 g·mol
3D model (JSmol)	Interactive image
SMILES C12CCC(=O)C=C1CC324CC5(3CC5C(=O)CO)CO4
InChI InChI=1S/C21H28O4/c1-20-7-6-13(23)8-12(20)2-3-14-15-4-5-16(17(24)10-22)21(15)9-18(19(14)20)25-11-21/h8,14-16,18-19,22H,2-7,9-11H2,1H3/t14-,15-,16+,18-,19+,20-,21?/m0/s1 Key:ZEBLTAXSHAKMDJ-QBSCYWOBSA-N

18-Deoxyaldosterone is a steroidal antimineralocorticoid with mixed agonist–antagonist but predominantly antagonistic activity at the mineralocorticoid receptor.

References

1. "(11beta)-11,18-Epoxy-21-hydroxypregn-4-ene-3,20-dione".
2. Duax WL, Griffin JF, Strong PD, Funder JW, Ulick S (1982). "Molecular structure of 18-deoxyaldosterone and its relationship to receptor binding and activity". Journal of the American Chemical Society. 104 (25): 7291–7293. Bibcode:1982JAChS.104.7291D. doi:10.1021/ja00389a063. ISSN 0002-7863.

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