Misplaced Pages

5,7-Dichlorokynurenic acid

Article snapshot taken from[REDACTED] with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
5,7-Dichlorokynurenic acid
Names
Preferred IUPAC name 5,7-Dichloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
IUPHAR/BPS
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)Key: BGKFPRIGXAVYNX-UHFFFAOYSA-N
  • InChI=1/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)Key: BGKFPRIGXAVYNX-UHFFFAOYAD
SMILES
  • C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl
Properties
Chemical formula C10H5Cl2NO3
Molar mass 258.05 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

5,7-Dichlorokynurenic acid (DCKA) is a selective NMDA receptor antagonist acting at the glycine site of the NMDA receptor complex.

See also

References

  1. McNamara D, Smith EC, Calligaro DO, O'Malley PJ, McQuaid LA, Dingledine R. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neuroscience Letters. 1990 Nov 27;120(1):17-20. PMID 2149877
Ionotropic glutamate receptor modulators
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Stub icon

This drug article relating to the nervous system is a stub. You can help Misplaced Pages by expanding it.

Categories:
5,7-Dichlorokynurenic acid Add topic