Misplaced Pages

ARL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FZQ, 3BH6, 3BH7, 4GOJ
Identifiers
Aliases	ARL3, ARFL3, ADP ribosylation factor like GTPase 3, JBTS35, RP83
External IDs	OMIM: 604695; MGI: 1929699; HomoloGene: 48276; GeneCards: ARL3; OMA:ARL3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.32 Start 102,673,731 bp End 102,714,397 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C3 Start 46,519,535 bp End 46,561,637 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of paranasal sinus palpebral conjunctiva retinal pigment epithelium Pons pars compacta pars reticulata tibia epithelium of nasopharynx external globus pallidus Top expressed in neural layer of retina Epithelium of choroid plexus epithelium of lens retinal pigment epithelium motor neuron medullary collecting duct fossa substantia nigra Rostral migratory stream olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding microtubule binding GTP binding metal ion binding protein binding GTPase activity magnesium ion binding GTPase activating protein binding Cellular component cytoplasm centrosome Golgi apparatus cell projection membrane Golgi membrane spindle intracellular anatomical structure photoreceptor connecting cilium microtubule organizing center midbody spindle microtubule cytoplasmic microtubule extracellular exosome cytoskeleton nucleus cilium microtubule cytoskeleton Biological process cilium assembly kidney development intraciliary transport small GTPase mediated signal transduction photoreceptor cell development post-Golgi vesicle-mediated transport cell division protein transport cell cycle smoothened signaling pathway transport mitotic cytokinesis Golgi to plasma membrane transport protein localization to cilium protein localization to ciliary membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 403 56350 Ensembl ENSG00000138175 ENSMUSG00000025035 UniProt P36405 Q9WUL7 RefSeq (mRNA) NM_004311 NM_019718 NM_001355233 RefSeq (protein) NP_004302 NP_062692 NP_001342162 Location (UCSC) Chr 10: 102.67 – 102.71 Mb Chr 19: 46.52 – 46.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.

Function

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.

Interactions

ARL3 has been shown to interact with Protein unc-119 homolog.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000138175 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025035 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA (August 1994). "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues". J. Biol. Chem. 269 (29): 18937–42. doi:10.1016/S0021-9258(17)32257-3. PMID 8034651.
6. Kim HS (1998). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 83 (3–4): 246. doi:10.1159/000015194. PMID 10072593. S2CID 35440803.
7. ^ "Entrez Gene: ARL3 ADP-ribosylation factor-like 3".
8. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
9. Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.

External links

• Human ARL3 genome location and ARL3 gene details page in the UCSC Genome Browser.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Linari M, Hanzal-Bayer M, Becker J (1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner". FEBS Lett. 458 (1): 55–9. doi:10.1016/S0014-5793(99)01117-5. PMID 10518933. S2CID 23460401.
• Hillig RC, Hanzal-Bayer M, Linari M, Becker J, Wittinghofer A, Renault L (2000). "Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein". Structure. 8 (12): 1239–45. doi:10.1016/S0969-2126(00)00531-1. PMID 11188688.
• Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ (2002). "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C". J. Biol. Chem. 277 (17): 14629–34. doi:10.1074/jbc.M200128200. PMID 11847227.
• Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Grayson C, Bartolini F, Chapple JP, Willison KR, Bhamidipati A, Lewis SA, Luthert PJ, Hardcastle AJ, Cowan NJ, Cheetham ME (2002). "Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3". Hum. Mol. Genet. 11 (24): 3065–74. doi:10.1093/hmg/11.24.3065. PMID 12417528.
• Kühnel K, Veltel S, Schlichting I, Wittinghofer A (2006). "Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3". Structure. 14 (2): 367–78. doi:10.1016/j.str.2005.11.008. hdl:11858/00-001M-0000-0015-8B49-9. PMID 16472755.
• Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA (2006). "Arl2 and Arl3 regulate different microtubule-dependent processes". Mol. Biol. Cell. 17 (5): 2476–87. doi:10.1091/mbc.E05-10-0929. PMC 1446103. PMID 16525022.

This article on a gene on human chromosome 10 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 10
• Human chromosome 10 gene stubs