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ARPC5
Identifiers
Aliases	ARPC5, ARC16, dJ127C7.3, p16-Arc, actin related protein 2/3 complex subunit 5
External IDs	OMIM: 604227; MGI: 1915021; HomoloGene: 4176; GeneCards: ARPC5; OMA:ARPC5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q25.3 Start 183,620,846 bp End 183,635,783 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 G3 Start 152,642,293 bp End 152,651,348 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte germinal epithelium lower lobe of lung blood superficial temporal artery appendix trabecular bone granulocyte lymph node placenta Top expressed in granulocyte ileum spleen thymus stomach ganglionic eminence jejunum neural tube Mesencephalon placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding structural constituent of cytoskeleton protein binding actin binding Cellular component cytoplasm cytosol cell projection focal adhesion arp2/3 protein complex actin cytoskeleton extracellular exosome cytoskeleton neuron projection extracellular region endosome growth cone secretory granule lumen ficolin-1-rich granule lumen lamellipodium nucleus site of double-strand break Biological process Fc-gamma receptor signaling pathway involved in phagocytosis ephrin receptor signaling pathway regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation cell migration actin cytoskeleton organization actin filament network formation orbitofrontal cortex development lamellipodium organization smooth muscle cell migration maintenance of cell polarity neutrophil degranulation membrane organization microtubule organizing center localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10092 67771 Ensembl ENSG00000162704 ENSMUSG00000008475 UniProt O15511 Q9CPW4 RefSeq (mRNA) NM_005717 NM_001270439 NM_026369 RefSeq (protein) NP_001257368 NP_005708 NP_080645 Location (UCSC) Chr 1: 183.62 – 183.64 Mb Chr 1: 152.64 – 152.65 Mb PubMed search
Wikidata
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Actin-related protein 2/3 complex subunit 5 is a protein that in humans is encoded by the ARPC5 gene.

Function

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined.

Interactions

ARPC5 has been shown to interact with ARPC4.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000162704 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000008475 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (1997). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 ( Pt 1) (1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
6. Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (August 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J. Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
7. ^ "Entrez Gene: ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa".
8. Millard TH, Behrendt B, Launay S, Fütterer K, Machesky LM (2003). "Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5". Cell Motil. Cytoskeleton. 54 (1): 81–90. doi:10.1002/cm.10087. PMID 12451597.
9. Zhao X, Yang Z, Qian M, Zhu X (2001). "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub". Biochem. Biophys. Res. Commun. 280 (2): 513–7. doi:10.1006/bbrc.2000.4151. PMID 11162547.

Further reading

• Welch MD, Iwamatsu A, Mitchison TJ (1997). "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes". Nature. 385 (6613): 265–9. Bibcode:1997Natur.385..265W. doi:10.1038/385265a0. PMID 9000076. S2CID 4358529.
• Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD (2001). "Crystal structure of Arp2/3 complex". Science. 294 (5547): 1679–84. Bibcode:2001Sci...294.1679R. doi:10.1126/science.1066333. PMID 11721045. S2CID 18088124.
• Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD (2001). "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity". Mol. Cell. 8 (5): 1041–52. doi:10.1016/S1097-2765(01)00393-8. PMID 11741539.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Singh S, Powell DW, Rane MJ, Millard TH, Trent JO, Pierce WM, Klein JB, Machesky LM, McLeish KR (2003). "Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis". J. Biol. Chem. 278 (38): 36410–7. doi:10.1074/jbc.M306428200. PMID 12829704.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• ARPC5 human gene location in the UCSC Genome Browser.
• ARPC5 human gene details in the UCSC Genome Browser.

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