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Acenocoumarol

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	X
Routes of administration	Oral
ATC code	B01AA07 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	8 to 11 hours
Identifiers
IUPAC name (RS)-4-hydroxy-3--2H-chromen-2-one
CAS Number	152-72-7
PubChem CID	9052
DrugBank	DB01418
ChemSpider	10443441
UNII	I6WP63U32H
KEGG	D07064
ChEBI	CHEBI:53766
ChEMBL	ChEMBL397420
CompTox Dashboard (EPA)	DTXSID2022541
ECHA InfoCard	100.005.281
Chemical and physical data
Formula	C19H15NO6
Molar mass	353.330 g·mol
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
Melting point	196 to 199 °C (385 to 390 °F)
SMILES CC(=O)CC(C1=CC=C(C=C1)(=O))C2=C(OC3=CC=CC=C3C2=O)O
InChI InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3 Key:VABCILAOYCMVPS-UHFFFAOYSA-N
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Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.

References

1. "International listings for acenocoumarol". Drugs.com.

Further reading

• Cesar JM, García-Avello A, Navarro JL, Herraez MV (October 2004). "Aging and oral anticoagulant therapy using acenocoumarol". Blood Coagulation & Fibrinolysis. 15 (8): 673–676. doi:10.1097/00001721-200412000-00007. PMID 15613922. S2CID 19214006.
• Lengyel M (December 2004). "". Orvosi Hetilap. 145 (52): 2619–2621. PMID 15724697.
• Ufer M (2005). "Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol". Clinical Pharmacokinetics. 44 (12): 1227–1246. doi:10.2165/00003088-200544120-00003. PMID 16372822. S2CID 42970169.
• Montes R, Ruiz de Gaona E, Martínez-González MA, Alberca I, Hermida J (April 2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients". British Journal of Haematology. 133 (2): 183–187. doi:10.1111/j.1365-2141.2006.06007.x. hdl:10171/21989. PMID 16611310. S2CID 369821.

External links

• Diseases Database (DDB): 29202

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• Vitamin K antagonists
• 4-Nitrophenyl compounds
• Coumarin drugs
• 4-Hydroxycoumarins
• Blood and blood forming organ drug stubs