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In enzymology, an albendazole monooxygenase (EC 1.14.13.32) is an enzyme that catalyzes the chemical reaction

albendazole + NADPH + H + O₂ ${\displaystyle \rightleftharpoons }$ albendazole S-oxide + NADP + H₂O

The four substrates of this enzyme are albendazole, NADPH, H, and O₂, whereas its three products are albendazole S-oxide, NADP, and H₂O.

This enzyme is coded by the gene for CYP3A4 and belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming). Other names in common use include albendazole oxidase, and albendazole sulfoxidase. It employs one cofactor, FAD.

References

1. "Showing Protein Cytochrome P450 3A4 (HMDBP01018)". Human Metabolome Database. Retrieved 2017-08-05.
2. Enzyme 1.14.13.32 at KEGG

• Fargetton X, Galtier P, Delatour P (1986). "Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes". Vet. Res. Commun. 10 (4): 317–324. doi:10.1007/BF02213995. PMID 3739217.

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