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Amikhelline

Clinical data
ATC code	none
Pharmacokinetic data
Metabolism	none
Identifiers
IUPAC name 9-(2-diethylaminoethoxy)-4-hydroxy-7-methylpyranobenzoxol-5-one
CAS Number	4439-67-2
PubChem CID	71198
ChemSpider	64334
UNII	BD9T227F6M
ChEMBL	ChEMBL2104025
CompTox Dashboard (EPA)	DTXSID20196151
Chemical and physical data
Formula	C18H21NO5
Molar mass	331.368 g·mol
3D model (JSmol)	Interactive image
SMILES O=C/1c3c(O\C(=C\1)C)c(OCCN(CC)CC)c2occc2c3O
InChI InChI=1S/C18H21NO5/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18/h6,8,10,21H,4-5,7,9H2,1-3H3 Key:QZBPFSZZMYTRIA-UHFFFAOYSA-N
(verify)

Amikhelline is an antimitotic drug. It acts as a DNA intercalator and inhibits DNA polymerase.

References

1. Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP (1985). "". Comptes Rendus des Séances de la Société de Biologie et de ses Filiales. 179 (3): 331–9. PMID 2417673.
2. Rucheton M, Jeanteur P (1973). "Studies on amikhellin. I. Intercalative binding to double-stranded DNA". Biochimie. 55 (11): 1415–20. doi:10.1016/s0300-9084(74)80548-1. PMID 4364376.
3. Rucheton M, Jeanteur P (1976). "Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus". Biochimie. 58 (6): 689–95. doi:10.1016/s0300-9084(76)80393-8. PMID 60141.

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• Drugs not assigned an ATC code
• Antineoplastic and immunomodulating drugs
• Benzofuran ethers at the benzene ring
• Furanochromones
• DNA intercalaters
• DNA polymerase inhibitors
• Diethylamino compounds
• Antineoplastic and immunomodulating drug stubs