Aminopeptidase I - Misplaced Pages

Aminopeptidase I (EC 3.4.11.22, aminopeptidase III, aminopeptidase yscI, leucine aminopeptidase IV, yeast aminopeptidase I) is an enzyme. This enzyme catalyses the following chemical reaction

Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide.

Aminoacyl-arylamides are poor substrates

References

Johnson MJ (1941). "Isolation and properties of a pure yeast polypeptidase". J. Biol. Chem. 137 (2): 575–586. doi:10.1016/S0021-9258(19)56163-4.
Metz G, Röhm KH (May 1976). "Yeast aminopeptidase I. Chemical composition and catalytic properties". Biochimica et Biophysica Acta (BBA) - Enzymology. 429 (3): 933–49. doi:10.1016/0005-2744(76)90338-7. PMID 5147.
Chang YH, Smith JA (April 1989). "Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae". The Journal of Biological Chemistry. 264 (12): 6979–83. doi:10.1016/S0021-9258(18)83527-X. PMID 2651436.
Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ (March 1996). "Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I". The Journal of Cell Biology. 132 (6): 999–1010. doi:10.1083/jcb.132.6.999. PMC 2120762. PMID 8601598.

External links

Aminopeptidase+I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O
3.4.13	Dipeptidase 1 2 3
3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II
3.4.15	Angiotensin-converting enzyme
3.4.16	Serine type carboxypeptidases: Cathepsin A DD-Transpeptidase
3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II
Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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EC 3.4.11