The Asboe-Hansen sign (also known as "indirect Nikolsky sign'" or "Nikolsky II sign") refers to the extension of a large blister to adjacent unblistered skin when pressure is put on the top of it. It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions.
This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
It is considered an indirect diagnostic tool in toxic epidermal necrolysis (TEN).
See also
References
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- James, William; Berger, Timothy; Elston, Dirk (2005) Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Page 16. ISBN 0-7216-2921-0.
- Jonkman, Marcel F.; Horváth, Barbara (2022). "2. Dermatological examination of bullous diseases". In Horváth, Barbara (ed.). Autoimmune Bullous Diseases (2nd ed.). Switzerland: Springer. p. 13. ISBN 978-3-030-91557-5.
- James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "2. Cutaneous signs and diagnosis". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 13. ISBN 978-0-323-54753-6.
- Freiman, Anatoli; Kalia, Sunil; O'Brien, Elizabeth A. (July 2006). "Dermatologic Signs". Journal of Cutaneous Medicine and Surgery. 10 (4): 175–182. doi:10.2310/7750.2006.00042.
| Signs and symptoms relating to skin and subcutaneous tissue | |
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| Disturbances of skin sensation | |
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