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B777-81

Clinical data
Other names	BRN 6066682
Identifiers
IUPAC name 4-(1-methyl-4-phenylpiperidin-4-yl)oxyaniline
CAS Number	78104-11-7
PubChem CID	3060392
ChemSpider	2321322
CompTox Dashboard (EPA)	DTXSID80228740
Chemical and physical data
Formula	C18H22N2O
Molar mass	282.387 g·mol
3D model (JSmol)	Interactive image
SMILES CN1CCC(CC1)(C2=CC=CC=C2)OC3=CC=C(C=C3)N
InChI InChI=1S/C18H22N2O/c1-20-13-11-18(12-14-20,15-5-3-2-4-6-15)21-17-9-7-16(19)8-10-17/h2-10H,11-14,19H2,1H3 Key:GNVZOTBLCYEIRW-UHFFFAOYSA-N

B-777-81 is an antidepressant drug candidate.

B777-81 works by reversing reserpine and tetrabenazine-induced ptosis in a similar manner to that of imipramine, but with a shorter duration of action. It also antagonizes reserpine-induced hypothermia but it is without effect on the decrease in locomotor activity or catalepsy following reserpine. In vitro, B777-81 inhibited 5-HT uptake in platelets, potentiated the effect of NA on isolated vas deferens and had less anticholinergic effect than imipramine in the isolated ileum.

References

1. Eistetter K, Kley HP, Menge HG, Schaefer H (1983). "B-777-81". Drugs of the Future. 8 (5): 387. doi:10.1358/dof.1983.008.05.65796.
2. Ankier SI (1986). "4 Recent Progress in the Development of New Antidepressant Drugs". Progress in Medicinal Chemistry. Vol. 23. Elsevier. pp. 121–185. doi:10.1016/S0079-6468(08)70342-4. ISBN 978-0-444-80802-8. PMID 3310107.
3. Menge HG, Brand U, Kley HP (January 1985). "Classification of New CNS-active Compounds by a Two-lever Drug Discrimination Procedure". Pharmacopsychiatry. 18 (1): 141–142. doi:10.1055/s-2007-1017346.

• Experimental drugs
• Piperidines
• 4-Aminophenyl compounds