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BAG5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9D, 3A8Y
Identifiers
Aliases	BAG5, BAG-5, BCL2 associated athanogene 5, BAG cochaperone 5, CMD2F
External IDs	OMIM: 603885; MGI: 1917619; HomoloGene: 3584; GeneCards: BAG5; OMA:BAG5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.33 Start 103,556,545 bp End 103,562,657 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 F1 Start 111,675,922 bp End 111,679,691 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis skin of thigh skin of hip endothelial cell caput epididymis gums corpus epididymis gingival epithelium Top expressed in seminiferous tubule spermatid saccule otic vesicle spermatocyte otic placode supraoptic nucleus dorsal striatum interventricular septum aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chaperone binding protein binding protein kinase binding ubiquitin protein ligase binding adenyl-nucleotide exchange factor activity Cellular component cytosol membrane mitochondrion inclusion body perinuclear region of cytoplasm nucleus Biological process neuron death negative regulation of neuron projection development Golgi organization regulation of inclusion body assembly negative regulation of protein ubiquitination protein folding negative regulation of ubiquitin-protein transferase activity negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cellular response to heat negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of protein refolding regulation of ubiquitin-protein transferase activity protein stabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9529 70369 Ensembl ENSG00000166170 ENSMUSG00000049792 UniProt Q9UL15 Q8CI32 RefSeq (mRNA) NM_004873 NM_001015048 NM_001015049 NM_027404 NM_001324480 NM_001324481 NM_001324482 RefSeq (protein) NP_001015048 NP_001015049 NP_004864 NP_001311409 NP_001311410 NP_001311411 NP_081680 Location (UCSC) Chr 14: 103.56 – 103.56 Mb Chr 12: 111.68 – 111.68 Mb PubMed search
Wikidata
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BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000166170 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000049792 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
6. Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004). "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration". Neuron. 44 (6): 931–45. doi:10.1016/j.neuron.2004.11.026. PMID 15603737.
7. ^ "Entrez Gene: BAG5 BCL2-associated athanogene 5".

External links

• Human BAG5 genome location and BAG5 gene details page in the UCSC Genome Browser.

Further reading

• Takayama S, Sato T, Krajewski S, et al. (1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell. 80 (2): 279–84. doi:10.1016/0092-8674(95)90410-7. PMID 7834747.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Höhfeld J, Jentsch S (1997). "GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1". EMBO J. 16 (20): 6209–16. doi:10.1093/emboj/16.20.6209. PMC 1326305. PMID 9321400.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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