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BW247

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Noradrenaline antidepressant Pharmaceutical compound
BW 247
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC16H17N
Molar mass223.319 g·mol
3D model (JSmol)
SMILES
  • CNCC=C(C1=CC=CC=C1)C2=CC=CC=C2

BW-247 is an antidepressant.

BW-247 is a secondary amine, closely related in structure to the tricyclic antidepressants, which inhibits NA uptake in aortic strips and rat cerebral cortex slices. Unlike the tricyclic antidepressants, it is reported not to possess anticholinergic activity.

See also

References

  1. Castañer, J., Roberts, P. J. (1979). "BW-247". Drugs of the Future. 4 (2): 92. doi:10.1358/dof.1979.004.02.1002432.
  2. Ankier, S. I. (1986). "Progress in Medicinal Chemistry". 4 Recent Progress in the Development of New Antidepressant Drugs. Vol. 23. Elsevier. pp. 121–185. doi:10.1016/S0079-6468(08)70342-4.
  3. R.A. Maxwell, P.D. Keenan, E. Chaplin, B. Roth and S. Batimanglidj Eckhardt, J. Pharmacol. Exp. Ther., 166 (1969) 320.
  4. A.I. Salama, J.R. Insalaco and R.A. Maxwell, J. Pharmacol. Exp. Ther., 178 (1971) 474.
  5. J.W. Bridges, J.G. Dent and P. Johnson, Life Sci., 18 (1976) 97.
Antidepressants (N06A)
Specific reuptake inhibitors and/or receptor modulators
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
Tricyclic and tetracyclic antidepressants
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Monoamine oxidase inhibitors
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Adjunctive therapies
Miscellaneous
Monoamine reuptake inhibitors
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
See also: Receptor/signaling modulatorsMonoamine releasing agentsAdrenergicsDopaminergicsSerotonergicsMonoamine metabolism modulatorsMonoamine neurotoxins
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