Bertolucci is an Italian surname. Notable people with the surname include:
- Attilio Bertolucci (1911–2000), Italian poet and writer
- Bernardo Bertolucci (1941–2018), Italian film director and screenwriter
- Davide Bertolucci (born 1988), Italian footballer
- Giuseppe Bertolucci (1947–2012), Italian film director and screenwriter
- Paolo Bertolucci (born 1951), Italian tennis player
- Sergio Bertolucci (born 1950), Italian particle physicist
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