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CATSPER2
Identifiers
Aliases	CATSPER2, CatSper2, cation channel sperm associated 2
External IDs	OMIM: 607249; MGI: 2387404; HomoloGene: 77423; GeneCards: CATSPER2; OMA:CATSPER2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.3 Start 43,628,503 bp End 43,668,118 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 121,223,112 bp End 121,244,273 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis right hemisphere of cerebellum right testis left testis buccal mucosa cell anterior pituitary right uterine tube nipple right frontal lobe right lobe of thyroid gland Top expressed in seminiferous tubule spermatid spermatocyte soleus muscle submandibular gland gastrula primary oocyte neural layer of retina molar ankle More reference expression data BioGPS n/a
Gene ontology Molecular function calcium activated cation channel activity calcium channel activity voltage-gated ion channel activity ion channel activity protein binding voltage-gated sodium channel activity Cellular component integral component of membrane CatSper complex cell projection membrane plasma membrane cilium motile cilium Biological process cell differentiation membrane depolarization during action potential regulation of ion transmembrane transport ion transport multicellular organism development calcium ion transmembrane transport transmembrane transport spermatogenesis sperm-egg recognition calcium ion transport neuronal action potential flagellated sperm motility sodium ion transmembrane transport fertilization sperm capacitation response to progesterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117155 212670 Ensembl ENSG00000166762 ENSMUSG00000033486 UniProt Q96P56 A2ARP9 RefSeq (mRNA) NM_001282309 NM_001282310 NM_054020 NM_172095 NM_172097 NM_153075 RefSeq (protein) NP_001269238 NP_001269239 NP_742093 n/a Location (UCSC) Chr 15: 43.63 – 43.67 Mb Chr 2: 121.22 – 121.24 Mb PubMed search
Wikidata
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CatSper2, is a protein which in humans is encoded by the CATSPER2 gene. CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca-permeant ion channel specific essential for the correct function of sperm cells.

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.

See also

• Pseudogene (database)

References

1. ^ GRCh38: Ensembl release 89: ENSG00000166762 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000033486 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
6. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
7. *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-05. Retrieved 2008-12-16.
8. "Entrez Gene: CatSper2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636.
• Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. Bibcode:2001Natur.413..579G. doi:10.1038/35098164. PMID 11595929. S2CID 6099942.
• Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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