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CCDC6
Identifiers
Aliases	CCDC6, D10S170, H4, PTC, TPC, TST1, coiled-coil domain containing 6
External IDs	OMIM: 601985; MGI: 1923801; HomoloGene: 34786; GeneCards: CCDC6; OMA:CCDC6 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q21.2 Start 59,788,747 bp End 59,906,556 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B5.3 Start 69,932,951 bp End 70,029,030 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte parotid gland buccal mucosa cell skin of thigh skin of hip middle temporal gyrus saphenous vein parietal pleura caput epididymis jejunal mucosa Top expressed in zygote secondary oocyte primary oocyte vastus lateralis muscle knee joint tibialis anterior muscle ankle extensor digitorum longus muscle triceps brachii muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding structural constituent of cytoskeleton protein binding Cellular component cytoskeleton cytoplasm cytosol Biological process cytoskeleton organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8030 76551 Ensembl ENSG00000108091 ENSMUSG00000048701 UniProt Q16204 D3YZP9 RefSeq (mRNA) NM_005436 NM_001111121 RefSeq (protein) NP_005427 NP_001104591 Location (UCSC) Chr 10: 59.79 – 59.91 Mb Chr 10: 69.93 – 70.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Coiled-coil domain-containing protein 6 is a protein that in humans is encoded by the CCDC6 gene.

Interactions

CCDC6 has been shown to interact with PPP4C.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000108091 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000048701 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Grieco M, Cerrato A, Santoro M, Fusco A, Melillo RM, Vecchio G (Sep 1994). "Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo". Oncogene. 9 (9): 2531–5. PMID 8058316.
6. Anne-Spence M, Falk CT, Neiswanger K, Field LL, Marazita ML, Allen FH, Siervogel RM, Roche AF, Crandall BF, Sparkes RS (Sep 1984). "Estimating the recombination frequency for the PTC-Kell linkage". Human Genetics. 67 (2): 183–6. doi:10.1007/BF00272997. PMID 6745938. S2CID 8634962.
7. "Entrez Gene: CCDC6 coiled-coil domain containing 6".
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
9. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

External links

• Human CCDC6 genome location and CCDC6 gene details page in the UCSC Genome Browser.

Further reading

• Sato O (Mar 1976). "". No Shinkei Geka. Neurological Surgery. 4 (3): 211–7. PMID 775355.
• Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G (Feb 1990). "PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas". Cell. 60 (4): 557–63. doi:10.1016/0092-8674(90)90659-3. PMID 2406025. S2CID 22790995.
• Tong Q, Li Y, Smanik PA, Fithian LJ, Xing S, Mazzaferri EL, Jhiang SM (May 1995). "Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene". Oncogene. 10 (9): 1781–7. PMID 7753554.
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (Sep 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Celetti A, Cerrato A, Merolla F, Vitagliano D, Vecchio G, Grieco M (Jan 2004). "H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization". Oncogene. 23 (1): 109–21. doi:10.1038/sj.onc.1206981. PMID 14712216.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A (Sep 2007). "Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage". Oncogene. 26 (42): 6167–75. doi:10.1038/sj.onc.1210446. PMID 17420723.

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