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CLIC6
Identifiers
Aliases	CLIC6, CLIC1L, chloride intracellular channel 6
External IDs	OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.12 Start 34,668,994 bp End 34,718,227 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C4 Start 92,282,624 bp End 92,338,131 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium bronchial epithelial cell nasal epithelium caput epididymis palpebral conjunctiva epithelium of nasopharynx mucosa of paranasal sinus pancreatic epithelial cell olfactory zone of nasal mucosa pancreatic ductal cell Top expressed in Epithelium of choroid plexus epithelium of stomach retinal pigment epithelium olfactory epithelium ciliary body migratory enteric neural crest cell epithelium of small intestine yolk sac left colon efferent ductule More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated ion channel activity glutathione transferase activity chloride channel activity D2 dopamine receptor binding D3 dopamine receptor binding D4 dopamine receptor binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane chloride channel complex nucleus cytoplasm Biological process regulation of ion transmembrane transport chloride transport ion transport glutathione metabolic process chloride transmembrane transport transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54102 209195 Ensembl ENSG00000159212 ENSMUSG00000022949 UniProt Q96NY7 Q8BHB9 RefSeq (mRNA) NM_053277 NM_001317009 NM_172469 RefSeq (protein) NP_001303938 NP_444507 NP_766057 Location (UCSC) Chr 21: 34.67 – 34.72 Mb Chr 16: 92.28 – 92.34 Mb PubMed search
Wikidata
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Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.

The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3.

Function

CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells.

See also

• Chloride channel

References

1. ^ GRCh38: Ensembl release 89: ENSG00000159212 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022949 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
6. ^ "Entrez Gene: CLIC6 chloride intracellular channel 6".
7. Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
8. Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi:10.1016/j.jbc.2023.105349. PMC 10641671. PMID 37838179.

Further reading

• Singh H (May 2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–2121. Bibcode:2010FEBSL.584.2112S. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. S2CID 21056278.
• Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, et al. (August 2002). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q". Mammalian Genome. 13 (8): 456–462. doi:10.1007/s00335-001-2157-0. hdl:11586/196820. PMID 12226712. S2CID 26059147.
• Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, et al. (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
• Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
• Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, et al. (November 2003). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12". Gene. 320: 31–40. doi:10.1016/S0378-1119(03)00830-8. PMID 14597386.

External links

• CLIC6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CLIC6 genome location and CLIC6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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