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CNTROB
Identifiers
Aliases	CNTROB, LIP8, PP1221, centrobin, centriole duplication and spindle assembly protein
External IDs	OMIM: 611425; MGI: 2443290; HomoloGene: 14205; GeneCards: CNTROB; OMA:CNTROB - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,932,101 bp End 7,949,920 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B3 Start 69,299,487 bp End 69,323,775 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis ventricular zone body of uterus ganglionic eminence right lung upper lobe of left lung pancreatic ductal cell canal of the cervix cardiac muscle tissue of right atrium Top expressed in superior surface of tongue gallbladder ventricular zone otic vesicle neural layer of retina secondary oocyte spermatocyte zygote thymus primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein domain specific binding Cellular component centriole centrosome cytoskeleton cytoplasm cytosol Biological process cell cycle mitotic cytokinetic process centrosome separation cell division centriole replication regulation of cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116840 216846 Ensembl ENSG00000170037 ENSMUSG00000032782 UniProt Q8N137 Q8CB62 RefSeq (mRNA) NM_001037144 NM_053051 NM_001330124 NM_001353202 NM_001353203 NM_001353204 NM_001353205 NM_001353206 NM_001353207 NM_001353208 NM_001353209 NM_172560 RefSeq (protein) NP_001032221 NP_001317053 NP_444279 NP_001340131 NP_001340132 NP_001340133 NP_001340134 NP_001340135 NP_001340136 NP_001340137 NP_001340138 NP_766148 Location (UCSC) Chr 17: 7.93 – 7.95 Mb Chr 11: 69.3 – 69.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Centrobin is a protein that in humans is encoded by the CNTROB gene. It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000170037 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032782 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
6. Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology. 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.

External links

• Human CNTROB genome location and CNTROB gene details page in the UCSC Genome Browser.

Further reading

• Jeong Y, Lee J, Kim K, et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization". J. Cell Sci. 120 (Pt 12): 2106–16. doi:10.1242/jcs.03458. PMID 17535851.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Genes on human chromosome 17