Casalegno is a family name of Italian origin. Notable people with the surname include:
- Elenoire Casalegno (born 1976), Italian television presenter
- Gabriele Casalegno (born c. 1923), Italian rugby player
- Gavin Casalegno, (born 1999) American actor
- Mattia Casalegno, Italian artist
- Joel Casalegno, (born 1992) American United States Marine
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