Clomocycline - Misplaced Pages

Chemical compound Pharmaceutical compound

Clomocycline
Clinical data


Other names	(2Z,4S,4aS,5aS,6S,12aS)-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-2--6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
ATC code	J01AA11 (WHO)
Identifiers
IUPAC name (4S,4aS,5aS,6S,12aR)-7-Chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
CAS Number	1181-54-0
PubChem CID	54680675
DrugBank	DB00453
ChemSpider	16735748
UNII	YP0241BU76
KEGG	D06885
ChEMBL	ChEMBL2106071
CompTox Dashboard (EPA)	DTXSID80905089
Chemical and physical data
Formula	C₂₃H₂₅ClN₂O₉
Molar mass	508.91 g·mol
3D model (JSmol)	Interactive image
SMILES Clc1c4c(c(O)cc1)C(\O)=C3\C(=O)2(O)C(=O)/C(C(=O)(N(C)C)2C34(O)C)=C(\O)NCO
InChI InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-28,30-31,34-35H,6-7H2,1-3H3,(H,25,33)/t8?,9-,16-,22-,23-/m0/s1 Key:GJGDLRSSCNAKGL-BJNNJSPUSA-N
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Clomocycline is a tetracycline antibiotic. It is used to treat Pustulosis palmaris et plantaris.

References

Ward JM, Corbett MF, Hanna MJ (September 1976). "A double-blind trial of clomocycline in the treatment of persistent palmoplantar pustulosis". The British Journal of Dermatology. 95 (3): 317–322. doi:10.1111/j.1365-2133.1976.tb07020.x. PMID 788767. S2CID 38040660.

-mycin (Streptomyces)

-micin (Micromonospora)

other

Tetracyclines	Doxycycline Chlortetracycline Clomocycline Demeclocycline Eravacycline Lymecycline Meclocycline Metacycline Minocycline Omadacycline Oxytetracycline Penimepicycline Rolitetracycline Sarecycline Tetracycline
Glycylcyclines	Tigecycline

Amphenicols	Chloramphenicol Azidamfenicol Thiamphenicol Florfenicol

Macrolides	Azithromycin Boromycin Carbomycin Carrimycin Clarithromycin Dirithromycin Erythromycin Flurithromycin Gamithromycin Josamycin Kitasamycin Midecamycin Miocamycin Nafithromycin Oleandomycin Rokitamycin Roxithromycin Solithromycin Spiramycin Telithromycin Tildipirosin Tilmicosin Troleandomycin Tulathromycin Tylosin Tylvalosin
Ketolides	Telithromycin Cethromycin Solithromycin
Lincosamides	Clindamycin Lincomycin Pirlimycin
Streptogramins	Pristinamycin (IA, IIA, IIB) NXL103 (Flopristin, Linopristin) Quinupristin/dalfopristin (Dalfopristin, Quinupristin) Streptogramin A Streptogramin B Virginiamycin (S1)

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