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Comorbidity–polypharmacy score

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Measure of severity of comorbidities

In medicine, the Comorbidity–polypharmacy score (CPS) is a measure of overall severity of comorbidities. It is defined as the simple sum of the number of known comorbidities (concurrent conditions) and pre-admission medications taken by the patient (polypharmacy), as a surrogate for the “intensity” of the comorbidities.

This score has been tested and validated extensively in the trauma population, demonstrating good correlation with mortality, morbidity, triage, and hospital readmissions. Increasing levels of CPS were associated with significantly lower 90-day survival in the original study of the score in trauma population.

Comparison with other comorbidity measures

The test is similar to the Charlson Comorbidity Index (CCI), but CPS also considers the number of medications taken, which is not a parameter in CCI. Additionally, CPS considers a wider range of comorbidities than CCI, and assigns the same weight to each. A study comparing the two metrics found that CCI was a better predictor of mortality than CPS in older trauma patients.

See also

References

  1. Khanh, Linh Ngo; Helenowski, Irene B.; Hoel, Andrew W.; Ho, Karen J. (2020-11-01). "The Comorbidity-Polypharmacy Score is an Objective and Practical Predictor of Outcomes and Mortality after Vascular Surgery". Annals of Vascular Surgery. 69: 206–216. doi:10.1016/j.avsg.2020.05.055. ISSN 0890-5096. PMID 32502672. S2CID 219398575.
  2. ^ Stawicki, Stanislaw P.; Kalra, Sarathi; Jones, Christian; Justiniano, Carla F.; Papadimos, Thomas J.; Galwankar, Sagar C.; Pappada, Scott M.; Feeney, John J.; Evans, David C. (2015). "Comorbidity polypharmacy score and its clinical utility: A pragmatic practitioner's perspective". Journal of Emergencies, Trauma, and Shock. 8 (4): 224–231. doi:10.4103/0974-2700.161658. ISSN 0974-2700. PMC 4626940. PMID 26604529.
  3. ^ Evans, DC; Cook, CH; Christy, JM (August 2012). "Comorbidity–polypharmacy scoring facilitates outcome prediction in older trauma patients". J Am Geriatr Soc. 60 (8): 1465–70. doi:10.1111/j.1532-5415.2012.04075.x. PMID 22788674. S2CID 40542659.
  4. Justiniano, CF; Coffey, RA; Evans, DC (Jan 2015). "Comorbidity–polypharmacy score predicts in-hospital complications and the need for discharge to extended care facility in older burn patients". J Burn Care Res. 36 (1): 193–96. doi:10.1097/bcr.0000000000000094. PMID 25559732. S2CID 3677354.
  5. Justiniano, CF; Evans, DC; Cook, CH (May 2013). "Comorbidity–polypharmacy score: a novel adjunct in post-emergency department trauma triage". J Surg Res. 181 (1): 16–19. doi:10.1016/j.jss.2012.05.042. PMC 3717608. PMID 22683074.
  6. Chua, Mui Teng; Pan, Darius Shaw Teng; Lee, Ming Zhou; Thajudeen, Mohammed Zuhary; Rahman, Mohamed Madeena Faizur; Sheth, Irfan Abdulrahman; Ong, Victor Yeok Kein; Tang, Jonathan Zhe Ying; Wee, Choon Peng Jeremy; Kuan, Win Sen (April 2023). "Comparing Comorbidity Polypharmacy Score and Charlson Comorbidity Index in predicting outcomes in older trauma patients". Injury. 54 (4): 1113–1118. doi:10.1016/j.injury.2023.02.031. ISSN 1879-0267. PMID 36822915. S2CID 257002026.


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