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Corynoline

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Corynoline
Names
IUPAC name 13-Methylchelidonine
Systematic IUPAC name (5bR,6S,12bR)-5b,13-Dimethyl-5b,6,7,12b,13,14-hexahydro-2H,10H-benzodioxolodioxolophenanthridin-6-ol
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.208.689 Edit this at Wikidata
EC Number
  • 683-177-2
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1Key: IQUGPRHKZNCHGC-TYPHKJRUSA-N
  • InChI=1/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1Key: IQUGPRHKZNCHGC-TYPHKJRUBF
SMILES
  • O1c2c(OC1)c3c(cc2)5((N(C3)C)c4cc6OCOc6cc4C5O)C
Properties
Chemical formula C21H21NO5
Molar mass 367.401 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Corynoline is an acetylcholinesterase inhibitor isolated from Corydalis incisa.

References

  1. Kim, DK (2002). "Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase". Archives of Pharmacal Research. 25 (6): 817–9. doi:10.1007/bf02976997. PMID 12510831. S2CID 35891875.
Acetylcholine metabolism and transport modulators
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers
See also
Receptor/signaling modulators
Muscarinic acetylcholine receptor modulators
Nicotinic acetylcholine receptor modulators


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