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D75-4590

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D75-4590
Names
IUPAC name 1-{amino}-2-ethyl-3-methylpyridobenzimidazole-4-carbonitrile
Other names 4--3-ethyl-2-methyl-4a,9-diaza-3,4-dihydrofluorene-1-carbonitrile
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C21H27N5/c1-5-16-15(4)17(14-22)21-24-18-10-8-9-11-19(18)26(21)20(16)23-12-13-25(6-2)7-3/h8-11,23H,5-7,12-13H2,1-4H3Key: DMKNXKIUSPUYQP-UHFFFAOYSA-N
SMILES
  • CCc1c(c(c2nc3ccccc3n2c1NCCN(CC)CC)C#N)C
Properties
Chemical formula C21H27N5
Molar mass 349.473 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

D75-4590 is an antifungal pyridobenzimidazole derivative that inhibits β-glucan synthesis. D11-2040 and D21-6076 are antifungal derivatives of D75-4590.

References

  1. Kitamura, Akihiro; Someya, Kazuhiko; Hata, Masato; Nakajima, Ryohei; Takemura, Makoto (2008). "Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis". Antimicrobial Agents and Chemotherapy. 53 (2): 670–7. doi:10.1128/AAC.00844-08. PMC 2630612. PMID 19015325.
  2. Kitamura, Akihiro; Someya, Kazuhiko; Okumura, Ryo; Hata, Masato; Takeshita, Hiroshi; Nakajima, Ryohei (2010). "In Vitro Antifungal Activities of D11-2040, a β-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs". Biological & Pharmaceutical Bulletin. 33 (2): 192–7. doi:10.1248/bpb.33.192. PMID 20118539.
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