Misplaced Pages

DHRS4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4R
Identifiers
Aliases	DHRS4, CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2, dehydrogenase/reductase (SDR family) member 4, dehydrogenase/reductase 4
External IDs	OMIM: 611596; MGI: 90169; HomoloGene: 49646; GeneCards: DHRS4; OMA:DHRS4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 23,953,734 bp End 23,969,279 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 C3|14 28.19 cM Start 55,716,215 bp End 55,727,797 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum human kidney mucosa of transverse colon monocyte apex of heart left adrenal cortex left ventricle gastrocnemius muscle right adrenal cortex Top expressed in right kidney human kidney proximal tubule left lobe of liver duodenum gallbladder submandibular gland brown adipose tissue Paneth cell saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity alcohol dehydrogenase signaling receptor binding oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor carbonyl reductase (NADPH) activity 3-keto sterol reductase activity NADP-retinol dehydrogenase activity Cellular component peroxisomal membrane peroxisome extracellular exosome endoplasmic reticulum membrane mitochondrion nucleus peroxisomal matrix cytosol Biological process steroid metabolic process alcohol metabolic process protein tetramerization cellular ketone metabolic process retinol metabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10901 28200 Ensembl ENSG00000157326 ENSG00000284807 ENSMUSG00000022210 UniProt Q9BTZ2 Q99LB2 RefSeq (mRNA) NM_001282987 NM_001282988 NM_001282989 NM_001282990 NM_001282991 NM_021004 NM_001037938 NM_030686 RefSeq (protein) NP_001269916 NP_001269917 NP_001269918 NP_001269919 NP_001269920 NP_066284 NP_001033027 NP_109611 Location (UCSC) Chr 14: 23.95 – 23.97 Mb Chr 14: 55.72 – 55.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dehydrogenase/reductase SDR family member 4 is an enzyme that in humans is encoded by the DHRS4 gene.

References

1. ^ ENSG00000284807 GRCh38: Ensembl release 89: ENSG00000157326, ENSG00000284807 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022210 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J. 340 ( Pt 2) (Pt 2): 561–8. doi:10.1042/bj3400561. PMC 1220285. PMID 10333503.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
7. "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4".

Further reading

• Song XH, Liang B, Liu GF, Li R, Xie JP, Du K, et al. (2007). "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma". Int. J. Cancer. 120 (8): 1618–26. doi:10.1002/ijc.22306. PMID 17230527.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Du J, Huang DY, Liu GF, Wang GL, Xu XL, Wang B, et al. (2004). "CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics". Yi Chuan Xue Bao. 31 (7): 661–7. PMID 15473316.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This protein-related article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 14
• Protein stubs