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In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is a long non-coding RNA molecule. In humans, the DISC2 gene that produces the DISC2 RNA molecule is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia. It is antisense to the DISC1 gene and may regulate the expression of DISC1. DISC2 may also contribute to other psychiatric disorders.

See also

• Long noncoding RNA

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. ^ Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics. 9 (9): 1415–1423. doi:10.1093/hmg/9.9.1415. hdl:20.500.11820/debc2b54-6e20-425f-9eab-dcd0c136cc98. PMID 10814723.
3. ^ Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID 15478311. S2CID 36081296.
4. Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK (Nov 2004). "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder". American Journal of Human Genetics. 75 (5): 862–872. doi:10.1086/425586. PMC 1182115. PMID 15386212.

Further reading

• Kato T (Jun 2001). "Molecular genetics of bipolar disorder". Neuroscience Research. 40 (2): 105–113. doi:10.1016/s0168-0102(01)00221-8. PMID 11377748. S2CID 44440932.
• Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ (Aug 2001). "Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family". American Journal of Human Genetics. 69 (2): 428–433. doi:10.1086/321969. PMC 1235314. PMID 11443544.
• Devon RS, Anderson S, Teague PW, Burgess P, Kipari TM, Semple CA, Millar JK, Muir WJ, Murray V, Pelosi AJ, Blackwood DH, Porteous DJ (Jun 2001). "Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder". Psychiatric Genetics. 11 (2): 71–78. doi:10.1097/00041444-200106000-00003. PMID 11525420. S2CID 10805910.
• Taylor MS, Devon RS, Millar JK, Porteous DJ (Jan 2003). "Evolutionary constraints on the Disrupted in Schizophrenia locus". Genomics. 81 (1): 67–77. doi:10.1016/S0888-7543(02)00026-5. PMID 12573262.
• Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID 15478311. S2CID 36081296.
• Farmer A, Elkin A, McGuffin P (Jan 2007). "The genetics of bipolar affective disorder". Current Opinion in Psychiatry. 20 (1): 8–12. doi:10.1097/YCO.0b013e3280117722. PMID 17143075. S2CID 1512643.
• Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK (Jan 2008). "The DISC locus in psychiatric illness". Molecular Psychiatry. 13 (1): 36–64. doi:10.1038/sj.mp.4002106. PMID 17912248.
• Williams JM, Beck TF, Pearson DM, Proud MB, Cheung SW, Scott DA (Aug 2009). "A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder". American Journal of Medical Genetics Part A. 149A (8): 1758–1762. doi:10.1002/ajmg.a.32941. PMC 2909829. PMID 19606485.

• Human genes
• Non-coding RNA