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It was received positively by music critics. Reviewing the Born Again album, Rolling Stone wrote a positive overview: "The only real find here is the awesome 'Dead Wrong', which shows B.I.G. in his prime." A.V. Club wrote that Eminem is a highlight.
Music video
The video was set out in a similar manner to Tupac's song "Changes", which was released in 1998, in the fact that it features clips of Biggie performing live, in interviews, clips of his music videos and showing pictures of him. Eminem appears in the video in a separate clip, rapping his lyrics in the style of a freestyle video submission. The YouTube version of the video doesn't feature him.
In other media
This song was mashed up with Led Zeppelin's "Whole Lotta Love" from the 2006/2007 mixtapeRock Phenomenon, which features the alternate second verse coming from the Notorious B.I.G. in legacy. The line "relax and take notes" is also put in a mix for the mixtape introduction, provided and contributed by DJ Vlad & Roc Raida with Linkin Park's Mike Shinoda as the host for the album. The song was also sampled in the song "Relax And Take Notes", a song by 8Ball & MJG which features Project Pat, from their 2007 album Ridin High. The last verse and hook were performed at the Up in Smoke Tour by Eminem and D12 member Proof.