| diacylglycerol cholinephosphotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.8.2 | ||||||||
| CAS no. | 9026-13-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction
CMP + a phosphatidylcholine
Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.
Classification
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.
Nomenclature
The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:
- 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
- 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
- 1-alkyl-2-acetylglycerol cholinephosphotransferase,
- alkylacylglycerol choline phosphotransferase,
- alkylacylglycerol cholinephosphotransferase,
- CDP-choline diglyceride phosphotransferase,
- cholinephosphotransferase,
- CPT,
- cytidine diphosphocholine glyceride transferase,
- cytidine diphosphorylcholine diglyceride transferase,
- diacylglycerol choline phosphotransferase,
- phosphocholine diacylglyceroltransferase,
- phosphorylcholine-glyceride transferase, and
- sn-1,2-diacylglycerol cholinephosphotransferase.
Biological role
This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
References
- Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities". J. Biol. Chem. 252 (9): 3050–6. PMID 192727.
- Lee TC, Blank ML, Fitzgerald V, Snyder F (1982). "Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver". Biochim. Biophys. Acta. 713 (2): 479–83. doi:10.1016/0005-2760(82)90269-7. PMID 6295501.
- Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ (1978). "Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate". Lipids. 13 (2): 161–4. doi:10.1007/BF02533260. PMID 204847.
- Renooij W, Snyder F (1981). "Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues". Biochim. Biophys. Acta. 663 (2): 545–56. doi:10.1016/0005-2760(81)90182-x. PMID 6260215.
| Transferases: phosphorus-containing groups (EC 2.7) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2.7.1-2.7.4: phosphotransferase/kinase (PO4) |
| ||||||||||||||
| 2.7.6: diphosphotransferase (P2O7) | |||||||||||||||
| 2.7.7: nucleotidyltransferase (PO4-nucleoside) |
| ||||||||||||||
| 2.7.8: miscellaneous |
| ||||||||||||||
| 2.7.10-2.7.13: protein kinase (PO4; protein acceptor) |
| ||||||||||||||
| Enzymes | |
|---|---|
| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
| Types |
|
This EC 2.7 enzyme-related article is a stub. You can help Misplaced Pages by expanding it. |