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EA-3834

Identifiers
IUPAC name (1-methylpiperidin-4-yl) 2-hydroxy-3-methyl-2-phenylbutanoate
CAS Number	75321-25-4
PubChem CID	21150216
ChemSpider	20085385
UNII	T4DW85YV8K
CompTox Dashboard (EPA)	DTXSID101028494
Chemical and physical data
Formula	C17H25NO3
Molar mass	291.391 g·mol
3D model (JSmol)	Interactive image
SMILES C1CN(C)CCC1OC(=O)C(O)(C(C)C)c2ccccc2
InChI InChI=1S/C17H25NO3/c1-13(2)17(20,14-7-5-4-6-8-14)16(19)21-15-9-11-18(3)12-10-15/h4-8,13,15,20H,9-12H2,1-3H3 Key:IFXNWEDGILPSBA-UHFFFAOYSA-N
(verify)

EA-3834 is a potent anticholinergic deliriant drug with a fairly long duration of action, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

EA-3834 has a potency and central to peripheral effects ratio only slightly less than that of related compounds such as EA-3443, and is faster acting and shorter lasting, although not as much as other compounds such as 302196.

EA-3834 appears to cause renal problems, among them, microhematuria.

See also

• CAR-302,668
• Edgewood Arsenal human experiments
• EA-3167
• N-methyl-3-piperidyl benzilate
• N-ethyl-3-piperidyl benzilate
• 3-Quinuclidinyl benzilate
• Ditran

References

1. Commission on Life Sciences (1982). "N-Methyl-4-piperidinyl-(phenylisopropyl)-glycolate (EA 3834)". Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Vol. 1. The National Academies Press. pp. 200–204. doi:10.17226/740. ISBN 978-0-309-07759-0. PMID 25032448.
2. Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc. ISBN 978-1-4243-0080-8.
3. Khatchadourian, Raffi (December 9, 2012). "Operation Delirium". newyorker.com. Retrieved May 18, 2021. Another version , called EA 3834, appeared to cause microscopic hematuria—tiny amounts of blood in urine—and other renal problems.

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• Deliriants
• Muscarinic antagonists
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• Piperidines
• Tertiary alcohols
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