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In enzymology, an enoyl- reductase (NADPH, A-specific) (EC 1.3.1.39) is an enzyme that catalyzes the chemical reaction

acyl- + NADP ${\displaystyle \rightleftharpoons }$ trans-2,3-dehydroacyl- + NADPH + H

Thus, the two substrates of this enzyme are ]] and NADP, whereas its 3 products are ]], NADPH, and H.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-:NADP+ oxidoreductase (A-specific). Other names in common use include acyl-ACP dehydrogenase, enoyl- (reduced nicotinamide adenine, dinucleotide phosphate) reductase, NADPH 2-enoyl Co A reductase, enoyl-ACp reductase, and enoyl- reductase (NADPH2, A-specific).

References

• Dugan RE, Slakey LL, Porter JW (1970). "Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis". J. Biol. Chem. 245 (23): 6312–6. PMID 4394955.

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