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C1QTNF12
Identifiers
Aliases	C1QTNF12, C1QDC2, CTRP12, FAM132A, family with sequence similarity 132 member A, C1q and TNF related 12
External IDs	OMIM: 616593; MGI: 1914639; HomoloGene: 12123; GeneCards: C1QTNF12; OMA:C1QTNF12 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.33 Start 1,242,446 bp End 1,246,722 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 87.66 cM Start 156,046,775 bp End 156,051,086 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of ileum jejunal mucosa duodenum testicle gonad skin of abdomen gastric mucosa skin of limb skin of leg Top expressed in medullary collecting duct renal corpuscle Epithelium of choroid plexus efferent ductule condyle fossa retinal pigment epithelium Paneth cell brown adipose tissue external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function hormone activity Cellular component extracellular region extracellular space Biological process positive regulation of glucose import negative regulation of gluconeogenesis positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin receptor signaling pathway positive regulation of protein kinase B signaling regulation of glucose metabolic process negative regulation of inflammatory response regulation of glucose import regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388581 67389 Ensembl ENSG00000184163 ENSMUSG00000023571 UniProt Q5T7M4 Q8R2Z0 RefSeq (mRNA) NM_001014980 NM_026125 RefSeq (protein) NP_001014980 NP_080401 Location (UCSC) Chr 1: 1.24 – 1.25 Mb Chr 4: 156.05 – 156.05 Mb PubMed search
Wikidata
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Family with sequence similarity 132, member A also known as adipolin is a protein that in humans is encoded by the FAM132A gene. Adipolin is an adipokine.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000184163 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000023571 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Family with sequence similarity 132, member A".

Further reading

• Wei Z, Lei X, Seldin MM, Wong GW (October 2012). "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J. Biol. Chem. 287 (43): 35804–14. doi:10.1074/jbc.M112.365965. PMC 3476250. PMID 22942287.
• Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N (October 2011). "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552–8. doi:10.1074/jbc.M111.277319. PMC 3186379. PMID 21849507.
• Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O (January 2013). "Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140–2. doi:10.1136/annrheumdis-2012-201693. PMID 22736092. S2CID 20772682.

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