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FZR1

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(Redirected from FZR1 (gene)) Protein-coding gene in humans

FZR1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UI9

Identifiers
AliasesFZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
External IDsOMIM: 603619; MGI: 1926790; HomoloGene: 9444; GeneCards: FZR1; OMA:FZR1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for FZR1Genomic location for FZR1
Band19p13.3Start3,506,311 bp
End3,538,334 bp
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)
Chromosome 10 (mouse)Genomic location for FZR1Genomic location for FZR1
Band10|10 C1Start81,202,056 bp
End81,214,350 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • left testis

  • right testis

  • sural nerve

  • anterior pituitary

  • ganglionic eminence

  • skin of leg

  • right hemisphere of cerebellum

  • tendon of biceps brachii

  • stromal cell of endometrium
Top expressed in
  • spermatid

  • seminiferous tubule

  • ventricular zone

  • spermatocyte

  • interventricular septum

  • yolk sac

  • fetal liver hematopoietic progenitor cell

  • dentate gyrus of hippocampal formation granule cell

  • neural tube

  • primary visual cortex
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51343

56371

Ensembl

ENSG00000105325

ENSMUSG00000020235

UniProt

Q9UM11

Q9R1K5

RefSeq (mRNA)

NM_001136197
NM_001136198
NM_016263

NM_019757

RefSeq (protein)

NP_001129669
NP_001129670
NP_057347

NP_062731

Location (UCSC)Chr 19: 3.51 – 3.54 MbChr 10: 81.2 – 81.21 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.

Interactions

FZR1 has been shown to interact with CDC27 and FBXO5.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000105325Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000020235Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (1998-11-05). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–S4. Bibcode:1998CBio....8.1207K. doi:10.1016/S0960-9822(07)00510-6. ISSN 0960-9822. PMID 9811605. S2CID 17181162.
  6. Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Molecular Cell. 2 (2): 163–71. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353.
  7. Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (October 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Molecular and Cellular Biology. 20 (20): 7613–23. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321. PMID 11003657.
  8. "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)".
  9. Zhou Y, Ching YP, Ng RW, Jin DY (September 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". The Biochemical Journal. 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC 1223613. PMID 12797865.
  10. Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (November 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–10. Bibcode:1998CBio....8.1207K. doi:10.1016/S0960-9822(07)00510-6. PMID 9811605. S2CID 17181162.
  11. Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. S2CID 25403043.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9UM11 (Fizzy-related protein homolog) at the PDBe-KB.
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