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GD-42

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Chemical compound

GD-42
Names

Preferred IUPAC name 4,8-Dimethyl-4-oxo-3-oxa-5,8-dithia-4λ-phosphadecan-8-ium methyl sulfate
Other names Methylsulfomethylate
Identifiers
CAS Number	2562-54-1
3D model (JSmol)	Interactive image
ChemSpider	144645
PubChem CID	164986
CompTox Dashboard (EPA)	DTXSID70948485
InChI InChI=1S/C8H20O2PS2.CH4O4S/c1-5-10-11(3,9)12-7-8-13(4)6-2;1-5-6(2,3)4/h5-8H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1Key: AUACWHVUVIIDOR-UHFFFAOYSA-M
SMILES CCOP(=O)(C)SCC(C)CC.COS(=O)(=O)
Properties
Chemical formula	C₉H₂₃O₆PS₃
Molar mass	354.43 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Chemical compound

GD-42 (methylsulfomethylate) is an irreversible acetylcholinesterase inhibitor. It has a positively charged sulfonium group.

See also

References

Danilov, AF; Kvitko, IJ; Lavrentieva, VV; Michelson, MJ; Porai-Koshits, BA; Rozhkova, EK; Shelkovnikov, SA (April 1972). "Action of some bisquaternary derivatives of phthalic acids and related substances on neuromuscular transmission". British Journal of Pharmacology. 44 (4): 765–78. doi:10.1111/j.1476-5381.1972.tb07314.x. PMC 1665980. PMID 4339387.
Danilov, AF; Ivanov, YJ; Michelson, MJ (January 1976). "The influence of motor nerve tetanization on the effect of organophosphorus cholinesterase inhibitors on neuromuscular transmission". British Journal of Pharmacology. 56 (1): 115–23. doi:10.1111/j.1476-5381.1976.tb06966.x. PMC 1666757. PMID 175873.

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Acetylcholine metabolism and transport modulators

Enzyme
(modulators)

ChATTooltip Choline acetyltransferase

AChETooltip Acetylcholinesterase

BChETooltip Butyrylcholinesterase

Inhibitors: Affinine
Affinisine
Conodurine
Cymserine
Ladostigil
Profenamine (ethopropazine)
Rivastigmine
Tacrine
ZINC-12613047
Many of the other AChE inhibitors listed above

Transporter
(modulators)

CHTTooltip Choline transporter

Inhibitors: Hemicholinium-3 (hemicholine)
Triethylcholine

Enhancers: Coluracetam

VAChTTooltip Vesicular acetylcholine transporter

Inhibitors: Vesamicol

Release
(modulators)

SNAP-25Tooltip Synaptosomal-associated protein 25 inactivators: Botulinum toxin (A, C, E)

VAMPTooltip Vesicle-associated membrane protein inactivators: Botulinum toxin (B, D, F, G)

Others: Bungarotoxins (β-bungarotoxin, γ-bungarotoxin)

LPHNTooltip Latrophilin agonists: α-Latrotoxin

Others: Atracotoxins (e.g., robustoxin, versutoxin)
Crotoxin

See also: Receptor/signaling modulators; Muscarinic acetylcholine receptor modulators; Nicotinic acetylcholine receptor modulators

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