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In enzymology, a gentamicin 2"-nucleotidyltransferase (EC 2.7.7.46) is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + gentamicin ${\displaystyle \rightleftharpoons }$ diphosphate + 2"-nucleotidylgentamicin

Thus, the two substrates of this enzyme are nucleoside triphosphate and gentamicin, whereas its two products are diphosphate and 2''-nucleotidylgentamicin.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:gentamicin 2"-nucleotidyltransferase. Other names in common use include gentamicin 2"-adenylyltransferase, aminoglycoside adenylyltransferase, and gentamicin 2"-nucleotidyltransferase.

References

• Angelatou F, Litsas SB, Kontomichalou P (February 1982). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa". J. Antibiot. 35 (2). Tokyo: 235–44. doi:10.7164/antibiotics.35.235. PMID 6281224.
• Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H (December 1971). "The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B". J. Antibiot. 24 (12). Tokyo: 913–4. doi:10.7164/antibiotics.24.913. PMID 4946513.
• Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T (December 1971). "Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor". J. Antibiot. 24 (12). Tokyo: 911–2. doi:10.7164/antibiotics.24.911. PMID 4946512.

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