Gueguen is a French surname. Notable people with the surname include:
- Frédéric Gueguen (born 1970), French footballer
- Michel Gueguen (born 1951), French modern pentathlete
- Raoul Gueguen (born 1947), French modern pentathlete
See also
- Mount Guéguen, a mountain of Antarctica
- Guéguen Point, a headland of Antarctica
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