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HS6ST2
Identifiers
Aliases	HS6ST2, heparan sulfate 6-O-sulfotransferase 2, MRXSPM
External IDs	OMIM: 300545; MGI: 1354959; HomoloGene: 9277; GeneCards: HS6ST2; OMA:HS6ST2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq26.2 Start 132,626,015 bp End 132,961,395 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A5 Start 50,476,089 bp End 50,770,733 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 lateral nuclear group of thalamus renal medulla testicle middle temporal gyrus placenta ventricular zone entorhinal cortex Brodmann area 46 Top expressed in Epithelium of choroid plexus lateral septal nucleus Gonadal ridge lateral hypothalamus dorsomedial hypothalamic nucleus calvaria nucleus accumbens habenula dorsal striatum superior colliculus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity sulfotransferase activity heparan sulfate 6-O-sulfotransferase activity Cellular component integral component of membrane Golgi membrane membrane nucleoplasm Biological process heparan sulfate proteoglycan biosynthetic process, enzymatic modification glycosaminoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90161 50786 Ensembl ENSG00000171004 ENSMUSG00000062184 UniProt Q96MM7 Q80UW0 RefSeq (mRNA) NM_001077188 NM_147175 NM_001394073 NM_001394074 NM_147174 NM_001077202 NM_001290467 NM_001290468 NM_015819 RefSeq (protein) NP_001070656 NP_671704 NP_001070670 NP_001277396 NP_001277397 NP_056634 Location (UCSC) Chr X: 132.63 – 132.96 Mb Chr X: 50.48 – 50.77 Mb PubMed search
Wikidata
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Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene.

Function

Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration.

This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000171004 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000062184 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Heparan sulfate 6-O-sulfotransferase 2". Retrieved 2016-07-11.

Further reading

• Habuchi H, Miyake G, Nogami K, Kuroiwa A, Matsuda Y, Kusche-Gullberg M, Habuchi O, Tanaka M, Kimata K (2003). "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties". Biochem. J. 371 (Pt 1): 131–42. doi:10.1042/BJ20021259. PMC 1223259. PMID 12492399.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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