Hyaladherins, also known as hyaluronan-binding proteins, are proteins capable of binding to hyaluronic acid. Most hyaladherins belong to the Link module superfamily, including its main receptor CD44, hyalectans and TSG-6. In addition there is a diverse group of hyaladherins lacking a Link module; these include the receptor RHAMM, C1QBP (HABP1) and HABP2. The primary roles of hyaladherins are cell adhesion, structural support of the extracellular matrix (ECM) and cell signalling.
Due to the role of aberrant hyaluronic acid synthesis and degradation in various cancers, hyaladherins, as well as hyaluronic acid, are considered a promising target for cancer therapy.
See also
References
- Toole, B.P. (October 1990). "Hyaluronan and its binding proteins, the hyaladherins". Current Opinion in Cell Biology. 2 (5): 839–844. doi:10.1016/0955-0674(90)90081-O. PMID 1707285.
- ^ Day, A. J.; Prestwich, G. D. (20 November 2001). "Hyaluronan-binding Proteins: Tying Up the Giant". Journal of Biological Chemistry. 277 (7): 4585–4588. doi:10.1074/jbc.R100036200. PMID 11717315.
- Nikitovic, Dragana; Kouvidi, Katerina; Kavasi, Rafaela-Maria; Berdiaki, Aikaterini; N. Tzanakakis, George (21 May 2016). "Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer". Current Drug Delivery. 13 (4): 500–511. doi:10.2174/1567201813666151109103013. PMID 26549038.