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IGLL5
Identifiers
Aliases	IGLL5, IGL, IGLV, VL-MAR, immunoglobulin lambda like polypeptide 5
External IDs	MGI: 96529; HomoloGene: 131669; GeneCards: IGLL5; OMA:IGLL5 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.22 Start 22,887,780 bp End 22,896,111 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 A3|16 10.45 cM Start 16,678,535 bp End 16,681,849 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum bone marrow cells mucosa of transverse colon lymph node spleen tonsil appendix olfactory zone of nasal mucosa salivary gland Top expressed in bone marrow granulocyte embryo choroid plexus brown adipose tissue choroid plexus of fourth ventricle Region I of hippocampus proper inferior colliculi secondary oocyte CA3 field More reference expression data BioGPS n/a
Gene ontology Molecular function immunoglobulin receptor binding antigen binding Cellular component extracellular region blood microparticle extracellular exosome external side of plasma membrane immunoglobulin complex, circulating Biological process B cell receptor signaling pathway phagocytosis, recognition positive regulation of B cell activation phagocytosis, engulfment innate immune response defense response to bacterium complement activation, classical pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100423062 16136 Ensembl ENSG00000254709 ENSMUSG00000075370 UniProt B9A064 P20764 RefSeq (mRNA) NM_001256296 NM_001178126 NM_001190325 RefSeq (protein) NP_001171597 NP_001243225 NP_001177254 Location (UCSC) Chr 22: 22.89 – 22.9 Mb Chr 16: 16.68 – 16.68 Mb PubMed search
Wikidata
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Immunoglobulin lambda like polypeptide 5 is a protein that in humans is encoded by the IGLL5 gene.

Function

This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. .

References

1. ^ GRCh38: Ensembl release 89: ENSG00000254709 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000075370 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Immunoglobulin lambda like polypeptide 5". Retrieved 2017-10-23.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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