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Inositol nicotinate

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Chemical compound

Pharmaceutical compound
Inositol nicotinate
Clinical data
Trade namesHexopal
AHFS/Drugs.comInternational Drug Names
Routes of
administration		oral
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.026.806 Edit this at Wikidata
Chemical and physical data
FormulaC42H30N6O12
Molar mass810.732 g·mol
3D model (JSmol)
Melting point255 °C (491 °F)
SMILES
  • O=C(O6(OC(=O)c1cccnc1)(OC(=O)c2cccnc2)(OC(=O)c3cccnc3)(OC(=O)c4cccnc4)6OC(=O)c5cccnc5)c7cccnc7

Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements.

Mechanism of action

When ingested, inositol nicotinate breaks down into inositol and niacin. The niacin component helps widen blood vessels (vasodilation), lowers blood lipid levels (including cholesterol), and inhibits a protein involved in blood clotting.

Uses

Inositol nicotinate is used to treat blood circulation problems, including:

Some research shows it can improve symptoms of Raynaud's phenomenon over several weeks. However, its effectiveness in treating other conditions like:

  • High cholesterol
  • High blood pressure
  • Leg pain during exercise (due to poor circulation)

remains unclear, with studies producing mixed results.

Other proposed uses, such as for:

have insufficient supporting evidence.

Side effects

Inositol nicotinate is generally safe when taken by mouth, but possible side effects include:

It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin.

Precautions

Inositol nicotinate should be used with caution in individuals with certain conditions:

  • Diabetes: May raise blood sugar levels. Diabetic patients should monitor their blood sugar levels closely.
  • Liver disease or kidney disease: Niacin can accumulate in people with liver or kidney problems, potentially worsening their condition.
  • Bleeding disorders: Inositol nicotinate may slow blood clotting, increasing the risk of bleeding for individuals with clotting disorders or those undergoing surgery.
  • Gout: Large amounts of niacin may trigger gout attacks.

References

  1. ^ "Inositol Nicotinate". WebMD. Retrieved 11 September 2024.
  2. Tomlinson, B (2014). "Niacin and inositol hexanicotinate for hyperlipidaemia and vascular disease: new data and new uses for an old drug". Journal of Clinical Pharmacy and Therapeutics. 39 (1): 1–12.
  3. Head, A (1986). "Treatment of intermittent claudication with inositol nicotinate". Practitioner. 230 (1411): 49–54.
  4. "Niacin: The facts on flushing". BC Drug & Poison Information Centre. Retrieved 11 September 2024.
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