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K10 transport/localisation element (TLS)

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RNA family
K10 transport/localisation element (TLS)
Predicted secondary structure and sequence conservation of K10_TLS
Identifiers
SymbolK10_TLS
RfamRF00207
Other data
RNA typeCis-reg
Domain(s)Eukaryota
SOSO:0005836
PDB structuresPDBe

The K10 transport/localisation element (TLS) is a 44 nucleotide K10 TLS regulatory element from Drosophila melanogaster. K10 TLS is responsible for the transport and anterior localisation of K10 mRNA and acts to establish dorsoventral polarity in the oocyte. It was discovered by Julia Serano.

References

  1. Serano TL, Cohen RS (November 1995). "A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA". Development. 121 (11): 3809–3818. doi:10.1242/dev.121.11.3809. PMID 8582290.
  2. Guillemin K, Williams T, Krasnow MA (September 2001). "A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila". Nature Cell Biology. 3 (9): 848–851. doi:10.1038/ncb0901-848. PMID 11533666. S2CID 15530627.

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