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LPAR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z34, 4Z35, 4Z36
Identifiers
Aliases	LPAR1, receptor 1, lysophosphatidic acid receptor 1
External IDs	OMIM: 602282; MGI: 108429; HomoloGene: 1072; GeneCards: LPAR1; OMA:LPAR1 - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 B3|4 32.2 cM Start 58,435,255 bp End 58,553,898 bp
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in maxillary prominence calvaria mandibular prominence optic nerve autopod region hand foot decidua conjunctival fornix utricle BioGPS More reference expression data
Gene ontology Molecular function lysophosphatidic acid binding PDZ domain binding G protein-coupled receptor activity signal transducer activity protein binding lysophosphatidic acid receptor activity G-protein alpha-subunit binding phospholipid binding lipid binding Cellular component cytoplasm integral component of membrane endosome membrane plasma membrane dendritic spine endocytic vesicle integral component of plasma membrane dendritic shaft cell surface soma neuron projection Biological process positive regulation of Rho protein signal transduction positive regulation of smooth muscle cell chemotaxis G protein-coupled receptor signaling pathway neurogenesis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway negative regulation of neuron projection development positive regulation of cell death adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration bleb assembly positive regulation of dendritic spine development activation of phospholipase C activity cerebellum development cellular response to 1-oleoyl-sn-glycerol 3-phosphate brain development regulation of cell shape positive regulation of apoptotic process cell chemotaxis positive regulation of I-kappaB kinase/NF-kappaB signaling myelination oligodendrocyte development corpus callosum development cellular response to oxygen levels positive regulation of stress fiber assembly optic nerve development positive regulation of MAPK cascade signal transduction negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1902 14745 Ensembl ENSG00000198121 ENSMUSG00000038668 UniProt Q92633 P61793 RefSeq (mRNA) NM_001401 NM_057159 NM_001290486 NM_010336 NM_172989 RefSeq (protein) NP_001392 NP_476500 NP_001338326 NP_001338327 NP_001338328 NP_001338329 NP_001338330 NP_001338331 NP_001338332 NP_001338333 NP_001338334 NP_001338335 NP_001338336 NP_001338337 NP_001338338 NP_001338339 NP_001338340 NP_001338341 NP_001338342 NP_001338343 NP_001338344 NP_001338345 NP_001338346 NP_001338347 NP_001338348 NP_001338349 NP_001277415 NP_034466 NP_766577 Location (UCSC) n/a Chr 4: 58.44 – 58.55 Mb PubMed search
Wikidata
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Lysophosphatidic acid receptor 1 also known as LPA₁ is a protein that in humans is encoded by the LPAR1 gene. LPA₁ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Function

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.

Cancer

LPAR1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.

Evolution

Paralogues

Source:

• LPAR2
• LPAR3
• S1PR1
• S1PR3
• S1PR5
• S1PR4
• S1PR2
• CNR1
• MC3R
• MC5R
• MC4R
• GPR12
• MC2R
• GPR6
• CNR2
• GPR3
• MC1R
• GPR119

See also

• Lysophospholipid receptor

References

1. ^ GRCm38: Ensembl release 89: ENSMUSG00000038668 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1".
5. Hecht JH, Weiner JA, Post SR, Chun J (November 1996). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. doi:10.1083/jcb.135.4.1071. PMC 2133395. PMID 8922387.
6. An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (February 1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. doi:10.1006/bbrc.1997.6150. PMID 9070858.
7. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
8. ^ Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.
9. "GeneCards®: The Human Gene Database".

Further reading

• An S, Goetzl EJ, Lee H (1999). "Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate". J. Cell. Biochem. Suppl. 30–31: 147–57. PMID 9893266.
• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors". Mol. Pharmacol. 58 (6): 1188–96. doi:10.1124/mol.58.6.1188. PMID 11093753. S2CID 6936621.
• Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). "Lysophosphatidic acid: G-protein signalling and cellular responses". Curr. Opin. Cell Biol. 9 (2): 168–73. doi:10.1016/S0955-0674(97)80059-2. PMID 9069262.
• Fukushima N, Kimura Y, Chun J (1998). "A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151–6. Bibcode:1998PNAS...95.6151F. doi:10.1073/pnas.95.11.6151. PMC 27607. PMID 9600933.
• An S, Bleu T, Zheng Y, Goetzl EJ (1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.
• Cervera P, Tirard M, Barron S, et al. (2002). "Immunohistological localization of the myelinating cell-specific receptor LP(A1)". Glia. 38 (2): 126–36. doi:10.1002/glia.10054. PMID 11948806. S2CID 21222546.
• Hama K, Bandoh K, Kakehi Y, et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors". FEBS Lett. 523 (1–3): 187–92. Bibcode:2002FEBSL.523..187H. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830. S2CID 44924895.
• Van Leeuwen FN, Olivo C, Grivell S, et al. (2003). "Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1". J. Biol. Chem. 278 (1): 400–6. doi:10.1074/jbc.M210151200. hdl:2066/186398. PMID 12393875.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway". J. Cell Sci. 116 (Pt 10): 1969–80. doi:10.1242/jcs.00397. PMID 12668728.
• Shida D, Kitayama J, Yamaguchi H, et al. (2003). "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1". Cancer Res. 63 (7): 1706–11. PMID 12670925.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMC 3904432. PMID 14688263.
• Komuro Y, Watanabe T, Kitayama J, et al. (2004). "The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas". Hepatogastroenterology. 50 (54): 1770–3. PMID 14696401.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kaneider NC, Lindner J, Feistritzer C, et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267. S2CID 22590944.

External links

• "Lysophospholipid Receptors: LPA₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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