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Limbic system-associated membrane protein

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Protein found in neurons

Limbic system-associated membrane protein (LAMP) 64- to 68-kDa heavily glycosylated protein found in neurons, specifically it is distributed in cortical and subcortical regions of the limbic system. LAMP protein is expressed on the surface of somata and proximal dendrites of neurons where it integrates via glycosyl-phosphatidyl-inositol (GPI) anchor. Despite the name, LAMP is not expressed only in the limbic-associated areas, but also less intensely in the midbrain and hindbrain regions.

References

  1. Pimenta, A. F.; Fischer, I.; Levitt, P. (1996-05-08). "cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP)". Gene. 170 (2): 189–195. doi:10.1016/0378-1119(96)84698-1. ISSN 0378-1119. PMID 8666243.
  2. ^ Innos, Jürgen; Koido, Kati; Philips, Mari-Anne; Vasar, Eero (2013-03-26). "Limbic system associated membrane protein as a potential target for neuropsychiatric disorders". Frontiers in Pharmacology. 4: 32. doi:10.3389/fphar.2013.00032. ISSN 1663-9812. PMC 3607788. PMID 23532449.
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