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Lingual antimicrobial peptide

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Lingual antimicrobial peptide
Identifiers
OrganismBos Taurus
SymbolLAP
Entrez403090
RefSeq (mRNA)NM_203435.4
RefSeq (Prot)NP_982259.3
UniProtQ28880
Other data
Chromosome27: 6.23 - 6.24 Mb
Search for
StructuresSwiss-model
DomainsInterPro

Lingual antimicrobial peptide (LAP) is a beta-defensin found in bovine internal epithelial tissue, in particular, that of the digestive tract. It has antimicrobial activity against many different pathogens. It was first isolated from an inflamed cattle tongue, hence its designation as lingual. Since then it has been found more extensively throughout the body; its presence has even been detected in bovine milk. Its expression is selective and increases in inflamed areas. LAP may have a closer relationship with immune response than simple antimicrobial activity, such as an association with growth factor activity.

References

  1. Huttner KM, Brezinski-Caliguri DJ, Mahoney MM, Diamond G (February 1998). "Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract". The Journal of Nutrition. 128 (2 Suppl): 297S – 299S. doi:10.1093/jn/128.2.297s. PMID 9478010.
  2. Schonwetter BS, Stolzenberg ED, Zasloff MA (March 1995). "Epithelial antibiotics induced at sites of inflammation". Science. 267 (5204): 1645–8. Bibcode:1995Sci...267.1645S. doi:10.1126/science.7886453. PMID 7886453. S2CID 85415552.
  3. Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M (August 1997). "Epithelial antibiotic induced in states of disease". Proceedings of the National Academy of Sciences of the United States of America. 94 (16): 8686–90. Bibcode:1997PNAS...94.8686S. doi:10.1073/pnas.94.16.8686. PMC 23078. PMID 9238038.
  4. Isobe N, Nakamura J, Nakano H, Yoshimura Y (June 2009). "Existence of functional lingual antimicrobial peptide in bovine milk". Journal of Dairy Science. 92 (6): 2691–5. doi:10.3168/jds.2008-1940. PMID 19448002.
  5. Mak P, Wójcik K, Thogersen IB, Dubin A (November 1996). "Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins". Infection and Immunity. 64 (11): 4444–9. doi:10.1128/IAI.64.11.4444-4449.1996. PMC 174396. PMID 8890190.
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