MRS-1706 - Misplaced Pages

MRS-1706
Names

IUPAC name N-(4-Acetylphenyl)-2-acetamide
Other names MRS 1706
Identifiers
CAS Number	264622-53-9
3D model (JSmol)	Interactive image
ChemSpider	4313008
IUPHAR/BPS	3287
MeSH	C496145
PubChem CID	5139184
UNII	YEE5LME5K5
CompTox Dashboard (EPA)	DTXSID40408687
InChI InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)Key: ZKUCFFYOQOJLGT-UHFFFAOYSA-N InChI=1/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)Key: ZKUCFFYOQOJLGT-UHFFFAOYAX
SMILES CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C(=O)C
Properties
Chemical formula	C₂₇H₂₉N₅O₅
Molar mass	503.56
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

MRS-1706 is a selective inverse agonist for the adenosine A_2B receptor. It inhibits release of interleukins and has an antiinflammatory effect.

References

Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW (February 2007). "ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor". The Journal of Pharmacology and Experimental Therapeutics. 320 (2): 637–45. doi:10.1124/jpet.106.111203. PMID 17077318.
Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D (May 2008). "Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study". Journal of Neurochemistry. 105 (3): 904–9. doi:10.1111/j.1471-4159.2007.05191.x. PMID 18088370.
Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, et al. (June 2008). "Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells". Journal of Immunology. 180 (11): 7212–20. doi:10.4049/jimmunol.180.11.7212. PMC 3628765. PMID 18490720.

P2X
(ATPTooltip Adenosine triphosphate)

CNTsTooltip Concentrative nucleoside transporters	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone
ENTsTooltip Equilibrative nucleoside transporters	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline
PMATTooltip Plasma membrane monoamine transporter	Decynium-22

XOTooltip Xanthine oxidase	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat
Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others

Others

See also: Receptor/signaling modulators

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