Mantegazza is an Italian surname. Notable people with the surname include:
- Cristoforo Mantegazza (c.1430–1482), Italian sculptor
- Giacomo Mantegazza (1851–1920), Italian painter
- Paolo Mantegazza (1831–1910), Italian neurologist, physiologist, and anthropologist
- Sergio Mantegazza (born 1927), Swiss businessman, chairman and owner of Globus
- Virgilio Mantegazza (1889–1928), Italian fencer
- Walter Mantegazza (1952–2006), Uruguayan footballer
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