Meathead may refer to:
- Matt Mitrione, an American mixed martial artist, and former NFL football player
- Michael Stivic, a character on the American sitcom All in the Family
- Meathead, the first stage name of rapper Future
- Meathead (Tom and Jerry), a grayish brown alley cat who first appeared in the 1943 Tom and Jerry short Sufferin' Cats! and several shorts in both the classic and modern era
- "Meathead" Louis Green
- Meatheads Burgers & Fries, a restaurant with ten locations in Illinois
- an extraterrestrial character in the film Meatballs Part II
- a person addicted to the illegal substance "meat" in The 80s: A Look Back at the Tumultuous Decade 1980–1989
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