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Methanogen homoaconitase (EC 4.2.1.114, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming). This enzyme catalyses the following chemical reaction

(R)-2-hydroxybutane-1,2,4-tricarboxylate ${\displaystyle \rightleftharpoons }$ (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction)

(1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate ${\displaystyle \rightleftharpoons }$ (Z)-but-1-ene-1,2,4-tricarboxylate + H₂O

(1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H₂O ${\displaystyle \rightleftharpoons }$ (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.

References

1. Drevland RM, Jia Y, Palmer DR, Graham DE (October 2008). "Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis". The Journal of Biological Chemistry. 283 (43): 28888–96. doi:10.1074/jbc.m802159200. PMC 2662002. PMID 18765671.

External links

• Methanogen+homoaconitase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 4.2.1