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Milameline

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Chemical compound Pharmaceutical compound
Milameline
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • (E)-N-methoxy-1-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)methanimine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.220.595 Edit this at Wikidata
Chemical and physical data
FormulaC8H14N2O
Molar mass154.213 g·mol
3D model (JSmol)
SMILES
  • N(/OC)=C\C1=C\CCN(C)C1

Milameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued.

  • Changing the O-methyl aldoxime to an O-propargyl oxime instead gives a separate molecule called RU 35986.

See also

References

  1. Sedman AJ, Bockbrader H, Schwarz RD (1995). "Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease". Life Sciences. 56 (11–12): 877–882. doi:10.1016/0024-3205(95)00023-Y. PMID 10188788.
  2. Broadley KJ, Kelly DR (2001). "Muscarinic Receptor Agonists and Antagonists". Molecules. 6 (3): 142–193. doi:10.3390/60300142. ISSN 1420-3049. PMC 6236374.
Psychoanaleptics: Anti-dementia agents (ATC code N06D and others)
AChE inhibitor medications
Other medications
Experimental BACE inhibitors
Muscarinic acetylcholine receptor modulators
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
Categories:
Milameline Add topic