Misplaced Pages

PMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WUT, 3NR3, 4A1H, 4A1Y, 4A8Z, 4BVM, 4D6A, 4D6B
Identifiers
Aliases	PMP2, FABP8, M-FABP, MP2, P2, peripheral myelin protein 2, Myelin P2 protein, CMT1G
External IDs	OMIM: 170715; MGI: 102667; HomoloGene: 20589; GeneCards: PMP2; OMA:PMP2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.13 Start 81,440,326 bp End 81,447,439 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 A1|3 2.54 cM Start 10,244,911 bp End 10,248,989 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb superior vestibular nucleus trigeminal ganglion inferior ganglion of vagus nerve ventral tegmental area subthalamic nucleus external globus pallidus pars reticulata pars compacta internal globus pallidus Top expressed in blastocyst morula spermatocyte neural layer of retina skeletal muscle tissue quadriceps femoris muscle zone of skin testicle esophagus white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fatty acid binding cholesterol binding protein binding lipid binding transporter activity Cellular component cytoplasm myelin sheath extracellular exosome Biological process membrane organization transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5375 18857 Ensembl ENSG00000147588 ENSMUSG00000052468 UniProt P02689 P24526 RefSeq (mRNA) NM_002677 NM_001348381 NM_001030305 RefSeq (protein) NP_002668 NP_001335310 NP_001025476 Location (UCSC) Chr 8: 81.44 – 81.45 Mb Chr 3: 10.24 – 10.25 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene. Myelin protein P2 is a constituent of peripheral nervous system (PNS) myelin, also present in small amounts in central nervous system (CNS) myelin. As a structural protein, P2 is thought to stabilize the myelin membranes, and may play a role in lipid transport in Schwann cells. Structurally, P2 belongs to the family of cytoplasmic fatty acid-binding proteins (FABPs).

References

1. ^ GRCh38: Ensembl release 89: ENSG00000147588 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000052468 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K (Jan 1992). "Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin". Biochem Biophys Res Commun. 181 (1): 204–7. doi:10.1016/S0006-291X(05)81402-0. PMID 1720307.
6. Hayasaka K, Himoro M, Takada G, Takahashi E, Minoshima S, Shimizu N (Feb 1994). "Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2)". Genomics. 18 (2): 244–8. doi:10.1006/geno.1993.1462. PMID 8288226.
7. "Entrez Gene: PMP2 peripheral myelin protein 2".

Further reading

• Narayanan V, Barbosa E, Reed R, Tennekoon G (1988). "Characterization of a cloned cDNA encoding rabbit myelin P2 protein". J. Biol. Chem. 263 (17): 8332–7. doi:10.1016/S0021-9258(18)68481-9. PMID 2453513.
• Jones TA, Bergfors T, Sedzik J, Unge T (1988). "The three-dimensional structure of P2 myelin protein". EMBO J. 7 (6): 1597–604. doi:10.1002/j.1460-2075.1988.tb02985.x. PMC 457142. PMID 2458918.
• Ishaque A, Hofmann T, Eylar EH (1982). "The complete amino acid sequence of the rabbit P2 protein". J. Biol. Chem. 257 (2): 592–5. doi:10.1016/S0021-9258(19)68231-1. PMID 6172423.
• Suzuki M, Kitamura K, Sakamoto Y, Uyemura K (1983). "The complete amino acid sequence of human P2 protein". J. Neurochem. 39 (6): 1759–62. doi:10.1111/j.1471-4159.1982.tb08017.x. PMID 6183401. S2CID 43779591.
• Trapp BD, Dubois-Dalcq M, Quarles RH (1984). "Ultrastructural localization of P2 protein in actively myelinating rat Schwann cells". J. Neurochem. 43 (4): 944–8. doi:10.1111/j.1471-4159.1984.tb12828.x. PMID 6206203. S2CID 37059056.
• Narayanan V, Ripepi B, Jabs EW, et al. (1994). "Partial structure and mapping of the human myelin P2 protein gene" (PDF). J. Neurochem. 63 (6): 2010–3. doi:10.1046/j.1471-4159.1994.63062010.x. hdl:2027.42/65484. PMID 7525873. S2CID 17388921.
• Besançon R, Latour P, Lara K, et al. (2001). "Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2)". Hum. Mutat. 17 (3): 237. doi:10.1002/humu.11. PMID 11241848. S2CID 33419662.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 8 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 8
• Lipocalins
• Human chromosome 8 gene stubs