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Myrotoxin B

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Myrotoxin B
Identifiers
CAS Number
3D model (JSmol)
PubChem CID
UNII
SMILES
  • CC1=C2()((C)34(CO4)()(C3OC5=O)O2)(CO((O7)(/6O)7CCOC6=C/C/C=C\5)=O)C1OC(C)=O
Properties
Chemical formula C29H34O11
Molar mass 558.580 g·mol
Melting point 195 to 197 °C (383 to 387 °F; 468 to 470 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Myrotoxin B is a macrocyclic trichothecene first isolated in 1985. It was tested on Swiss mice and found to be very toxic, though not the most toxic of the three toxins that were tested at that time. It has also been isolated from Myrothecium roridum, a pathogen leaf spot that affects mulberry, though it is unknown if it is used as a pathotoxin.

References

  1. ^ Jarvis, B. B.; Lee, Y.-W.; Cömezoḡlu, F. T.; Cömezoḡlu, S. N.; Bean, G. A. (1985). "Myrotoxins: a new class of macrocyclic trichothecenes". Tetrahedron Letters. 26 (40): 4859–62. doi:10.1016/S0040-4039(00)94970-0.
  2. Schiefer, H. B.; Hancock, D. S.; Jarvis, B. B. (1989). "Toxicology of Novel Macrocyclic Trichothecenes, Baccharinoid B4, Myrotoxin B, and Roritoxin B". Zentralblatt für Veterinärmedizin. Reihe A. 36 (2): 152–60. doi:10.1111/j.1439-0442.1989.tb00715.x. ISSN 0514-7158. PMID 2501953.
  3. Murakami, R.; Shirata, A. (2005). "Myrotoxin B Detection from Mulberry Leaves Infected with Myrothecium roridum, cause Myrothecium Leaf Spot of Mulberry, and Possible Roles in Pathogenicity" (pdf). Japanese Journal of Phytopathology. 71 (2): 91–100. doi:10.3186/jjphytopath.71.91.
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