N-acetylpolyamine oxidase (EC 1.5.3.13 , hPAO-1 , mPAO , hPAO ) is an enzyme with systematic name N-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming) . This enzyme catalyses the following chemical reaction
(1) N-acetylspermidine + O2 + H2 O
⇌
{\displaystyle \rightleftharpoons }
putrescine + 3-acetamidopropanal + H2 O2
(2) N-acetylspermine + O2 + H2 O
⇌
{\displaystyle \rightleftharpoons }
2 O2 This enzyme also catalyses the reaction:
N,N-diacetylspermine + O2 + H2 O
⇌
{\displaystyle \rightleftharpoons }
1 -acetylspermidine + 3-acetamamidopropanal + H2 O2 . References
Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW (February 2003). "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion" . The Biochemical Journal . 370 (Pt 1): 19–28. doi :10.1042/BJ20021779 . PMC 1223169 . PMID 12477380 .
Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J (February 2005). "Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines" . The Journal of Biological Chemistry . 280 (8): 6595–601. doi :10.1074/jbc.M412788200 . PMID 15611107 .
Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA (July 2005). "Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity". Cancer Chemotherapy and Pharmacology . 56 (1): 83–90. doi :10.1007/s00280-004-0936-5 . PMID 15791459 .
Wu T, Yankovskaya V, McIntire WS (June 2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase" . The Journal of Biological Chemistry . 278 (23): 20514–25. doi :10.1074/jbc.M302149200 . PMID 12660232 .
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Enzymes Activity
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N1-acetylpolyamine oxidase
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