N2-citryl-N6-acetyl-N6-hydroxylysine synthase

N-citryl-N-acetyl-N-hydroxylysine synthase (EC 6.3.2.38, N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase, iucA (gene)) is an enzyme with systematic name citrate:N-acetyl-N-hydroxy-L-lysine ligase (ADP-forming). This enzyme catalyses the following chemical reaction

2 ATP + citrate + N-acetyl-N-hydroxy-L-lysine + H₂O

\rightleftharpoons

2 ADP + 2 phosphate + N-citryl-N-acetyl-N-hydroxy-L-lysine

This enzyme requires Mg.

References

Appanna DL, Grundy BJ, Szczepan EW, Viswanatha T (1984). "Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1". Biochim. Biophys. Acta. 801 (3): 437–443. doi:10.1016/0304-4165(84)90150-8.
Gibson F, Magrath DI (November 1969). "The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I". Biochimica et Biophysica Acta (BBA) - General Subjects. 192 (2): 175–84. doi:10.1016/0304-4165(69)90353-5. PMID 4313071.
Maurer PJ, Miller M (1982). "Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N-acetyl-N-hydroxylysine". J. Am. Chem. Soc. 104 (11): 3096–3101. doi:10.1021/ja00375a025.
de Lorenzo V, Bindereif A, Paw BH, Neilands JB (February 1986). "Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12". Journal of Bacteriology. 165 (2): 570–8. doi:10.1128/jb.165.2.570-578.1986. PMC 214457. PMID 2935523.
Challis GL (April 2005). "A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases". ChemBioChem. 6 (4): 601–11. doi:10.1002/cbic.200400283. PMID 15719346.

External links

N2-citryl-N6-acetyl-N6-hydroxylysine+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 6.3.2